EXTRA-LARGE DOG IS 89 lbs plus. Fiprofort Plus, the Generic of Frontline Plus, is a monthly topical flea and tick preventative for dogs and cats. Fiprofort Plus kills 100% of adult fleas on your pet within 18 hours and 100% of all ticks within 48 hours. Fiprofort Plus contains an insect growth regulator, S-methoprene, which kills flea eggs and larvae. It's effective against all stages of the brown dog tick, the American dog tick, the lone star tick and the deer tick (the major carrier of Lyme disease).